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Synapses are specialized sites that allow information to be passed between neurons. Their importance is highlighted by the fact that even minor synaptic abnormalities, caused by disease or neurotrauma, result in devastating neurological conditions. Understanding how CNS synapses are formed is therefore essential to our understanding of neurological disorders. The Fox Laboratory is interested in understanding the cellular and molecular mechanisms that drive two aspects of synapse formation—synaptic targeting and synaptic differentiation.